Abstract
Crosstalk between the activation and slow inactivation gates in Shaker potassium channels is now well-established. The activation gate perceives the conformation of the inactivation gate (Panyi and Deutsch, 2006, 2007). Closure of the inactivation gate speeds opening and slows closing of the activation gate, i.e., stabilizing the gate in the open configuration. If this coupling involves movement of the S6 transmembrane segment, then we predict state-dependent changes in accessibility of residues lining the channel cavity.
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