Abstract
A new series of 1,2,4- and 1,3,4-oxadiazole derivatives possessing 3-fluoro-4-methoxyphenyl moiety were efficiently synthesized and characterized by spectroscopic methods and elemental analysis. All the compounds were evaluated in vivo for their anti-inflammatory and analgesic properties, and were found to be low lethal as ascertained by the LD50 test. The present study suggests that three compounds were found to have good anti-inflammatory activity in the carrageenan-induced rat paw edema test, while a fair number of compounds showed significant analgesic activity in the tail flick test. In silico ADME properties of synthesized compounds were also analysed and showed potential to develop as good oral drug candidates.
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