Abstract
ABSTRACT:
 To develop the herbal drug with the least side effects, there are superior opportunities to discover the medicinal and other biological properties. Natural products serve as sources of beneficial chemical molecules. For this study, Bauhinia acuminata an important medicinal plant of the Indian subcontinent that belongs to the family Fabaceae was chosen. The plant is well known for its precautionary action in tuberculosis. It has been established to possess some pharmacological activities such as membranes Stabilizing activity1, antibacterial2, anti-nociceptive3, thrombolytic activity4, antioxidant5, anthelmintic6, anti-diarrheal7, Hepato-protective 8.
 Phytoconstituents present in Bauhinia acuminata obey Lipinski's rule (MiLog P <5) except Kaempferol-3-glucoside indicated their drug-likeness property. Rhoeagenine, 9, 12, 15-octadecatrienoic acid, and 9, 12-octadecadienoic acid are the phytoconstituents showing all types of binding with all types of receptors binding except Kinase inhibitor activity.
 Rhoeagenine, Alpha humulene, 9, 12, 15-octadecatrienoic acid, 9, 12-octadecadienoic acid, Alpha muurolol, Beta-sitosterol, Kaempferol-3-glucoside are the phytoconstituents that are free from any type of toxicity. The accurate prediction scores can be used as monographs by researchers and scientists for the development of potential Semisynthetic and synthetic drugs for multifarious usage.
Highlights
The prehistoric people have great consciousness of the tradition of medicinal plants as herbal medicines
Ii) Methods: Molinspiration Software: Structures of 13 phytochemical compounds selected for our work as given in Table 1 were drawn using online molinspiration for the calculation of molecular properties like MiLog P, Total polar surface area (TPSA), number of hydrogen bond donors and acceptors, molecular weight, number of atoms, number of rotatable bonds, etc., and bioactivity scores like GPCR ligands, kinase inhibitors, ion channel modulators, enzymes, and nuclear receptors
All the phytochemicals found to have molecular weight
Summary
The prehistoric people have great consciousness of the tradition of medicinal plants as herbal medicines. The Discovery of drugs in medicinal plants affords better and vital leads, besides diverse pharmacological activities such as cytotoxic, anti-diarrheal, antimicrobial, antiinflammatory, antioxidant, anthelmintic, anti-nociceptive, hemolytic activity. As per the recommendations of Ayurveda Bauhinia acuminata is the one of important medicinal plants for the treatment of disorders. Bark, leaves, stem, blooms, and Roots have been utilized. Chemical constituents present in Bauhinia acuminata leaves are palmitic acid, three phallic acid esters, gallic acid, and ursolic acid. The leaves and stems of B. acuminata have shown the presence of carbohydrate, saponins, phenolic compounds, flavonoids, oils, and fats, alkaloids, anthocyanoside, steroids, anthraquinone, Neelima Kudumula, IJSRM Volume 09 Issue 07 July 2021 [www.ijsrm.in]
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