Abstract
Molecular Profile of Human Papillomavirus–Positive Oropharyngeal Squamous Cell Carcinoma Stratified by Smoking Status
Highlights
Purpose/Objective(s): HPV-positive oropharyngeal squamous cell carcinoma (OPSCC) among smokers represents a distinct clinical entity with intermediate prognosis compared to HPV-positive never smokers and HPV-negative cases
We hypothesize a higher frequency of TP53 and CDKN2A mutations in HPV-positive OPSCC among heavy smokers
Materials/Methods: Targeted next-generation sequencing of >800 genes including all commonly mutated genes in cancer was performed in 66 HPV-positive OPSCC cases stratified by smoking status (10 pack years)
Summary
Purpose/Objective(s): HPV-positive oropharyngeal squamous cell carcinoma (OPSCC) among smokers represents a distinct clinical entity with intermediate prognosis compared to HPV-positive never smokers and HPV-negative cases. Molecular Profile of Human PapillomavirusePositive Oropharyngeal Squamous Cell Carcinoma Stratified by Smoking Status J.P. Zevallos,1 E. Abedi-Ardekani,3 A.F. Olshan,4 and N.N. Hayes5; 1University of North Carolina Hospitals, Chapel Hill, NC, 2Department of Otolaryngology/Head and Neck Surgery, University of North Carolina at Chapel Hill, Chapel Hill, NC, 3International Agency for Research on Cancer, Lyon, France, 4Gillings School of Global Public Health, University of North Carolina at Chapel Hill, Chapel Hill, NC, 5University of North Carolina School of Medicine, Chapel Hill, NC
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