Abstract
Hepatitis C Virus is a causative agents of liver cirrhosis, having highly diversified genome. Genotype study has important role in clinical setup and prognosis of hepatitis C virus infection. The aim of this was to investigate the prevalence and risk factors associated with hepatitis C virus genotypes in district Kohat, Khyber Pakhtunkhwa, Pakistan. Hepatitis C virus pre-infected patients (n = 600) were analyzed to assess circulating HCV genotypes, using reverse transcriptase approach. Moreover serum ALT levels were determined followed by correlation with genotypes. In current study cohort, majority of patients (62%) were, having elevated ALT (> 50 U/L). similarly patients with mixed HCV genotypes, 3a/3b have relatively higher ALT levels (~62) compared to 2a/3a (~43) and others. We found significant correlation (p = 0.002) of genotype 2a in connection with ALT (49.48) level. Similarly 3a, 3b, mixed as well as un-typeable genotypes correlations were also found highly significant (p <0.001) with their mean ALT levels (47.14, 31.58, 46.69 and 43.68) respectively. In our studied population, most prevalent genotypes were 3a (25%) followed by 3b (20%) and 2a (15%). Fifteen percent of patient’s infections were untypeable while in 10% patients mixed genotype were observed. Among total 30 (5%) were blood transfusion cases, 90(15%) surgical, 540 (90%) dentistry, 360 (60%) Barber, 492 (82%) Pricks, whereas 180 (30%) cases were those having early type of HCV/HBV infection in their family. In current study, genotypes 3a and 3b were more prevalent, with two potential risk factors; dentistry and barbers. Moreover, genotypes and ALT investigations were found to be more fruitful in prognosis as well as management of HCV infection. Keywords: HCV; Genotypes; ALT; Risk factors; Kohat http://dx.doi.org/10.19045/bspab.2017.60019
Highlights
Introduction hepatocellular carcinomaHCV is a singleHepatitis C Virus (HCV) is a singleHepatitis C Virus (HCV) is a leading stranded positive sense RNA virus belongs causative agent of liver cirrhosis and to the genus hepacivirus of FlaviviridaePublished by Bolan Society for Pure and Applied Biology family [1]
Hepatitis C Virus is a causative agents of liver cirrhosis, having highly diversified genome
Genotype study has important role in clinical setup and prognosis of hepatitis C virus infection. The aim of this was to investigate the prevalence and risk factors associated with hepatitis C virus genotypes in district Kohat, Khyber Pakhtunkhwa, Pakistan
Summary
Frequencies of ALT levels All the patients under study were followed for measuring their ALT levels up to six months with specific interval. We analyzed the ALT level in patients circulating mixed HCV genotypes in their sera, and were found that patients infected with 3a/3b genotypes have significantly high ALT level (~62%), followed by 2a/3a (~43%) compared to other co-infected HCV patients. These elevated ALT level signify a drastic effect of HCV among individuals (Figure 2). General prevalence of HCV genotype The high prevalence rate among different HCV genotypes was reported for 3a (25%), followed by 3b (20%), 2a (15%), 1a (5%) and 4 (5%). The genotypes prevalence in terms of age groups is reported as: genotype 1a was with high prevalence rate in age group of ≤20 years followed by 41-60 years; genotype 2a had high prevalence in age groups 21- 40 years, followed by age group of ≤20 years, 41-60 years with lowest rate in 61-80 years; genotype 2b was only reported in age group of 61-80 years; genotype 3a was found in all age groups with relatively equal frequency among all age groups (Table 3); genotype 3b was high in age groups of 41-60 years followed by 21- 40 years and 61-80 years with prevalence rate of 30% each; genotype 4 was only reported in age group of 61-80 years; The occurrence of mixed genotype was reported high in age groups 41-60 years and 61-80 years with 30% prevalence rate in each cases, whereas 6% rates were observed from the cohort of age 21- 40 years and ≤20 years; the prevalence rate of untypeable genotype was high in the age groups of 21-40 years followed by 61-80 years and 41-60 years with least frequency rate (9%) in ≤20 years among the cohort (Table 3 and Figure 3)
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
