Abstract
e12505 Background: High-grade gliomas are the most common primary brain tumors in adults and are virtually incurable. Currently, optimal management includes resection, postoperative radiation and chemotherapy with temozolomide. However, even when this most aggressive treatment is delivered, the median survival is just over a year. We hypothesized that insensitivity to chemotherapy can be attributed to 3 possible mechanisms: (a) alterations in DNA repair pathways; (b) alterations in cell cycle checkpoints; and (c) selection of cells with “stem-like” phenotypes. Methods: In a retrospective study, we analyzed tumor tissue from 58 patients that had surgical resection of their GBM or AA between Dec 02 and Dec 08. We also analyzed tumor tissue from 13 patients with resected recurrent disease. DNA repair proteins (MGMT, MSH2), death avoidance proteins (p53, pAKT, XIAP), and stem cell markers (Nestin, CD133, ABCG2) were detected by immunohistochemistry. Correlative analyses between each marker and Overall Surviva...
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