Abstract
Epstein–Barr virus (EBV) associated gastric carcinoma is a special form of gastric adenocarcinoma that arises against the background of clonal growth of EBV-infected epithelial cells of the gastric mucosa. This subtype of tumors has unique genetic and epigenetic features that determine its characteristic phenotype. Determination of the molecular features of EBV-associated gastric cancer made it possible to identify potential targets for drug therapy of this subtype of tumors. The review presents modern data on the epidemiology and pathogenesis of EBVassociated gastric cancer, describes its unique pathomorphological and molecular features. Particular attention is paid to the prognostic role of EBV infection and drug therapy potentially applicable to the treatment of EBV-positive gastric cancer.
Highlights
3отделение противоопухолевой лекарственной терапии АО «К 31 Сити»; Россия, 123112 Москва, Тестовская ул., 10; 4Московский научно-исследовательский онкологический институт им
Epstein–Barr virus (EBV) associated gastric carcinoma is a special form of gastric adenocarcinoma that arises against the background of clonal growth of EBV-infected epithelial cells of the gastric mucosa
Particular attention is paid to the prognostic role of EBV infection and drug therapy potentially applicable to the treatment of EBV-positive gastric cancer
Summary
3отделение противоопухолевой лекарственной терапии АО «К 31 Сити»; Россия, 123112 Москва, Тестовская ул., 10; 4Московский научно-исследовательский онкологический институт им. Что при ВЭБ-инфекции с высокой частотой встречается метилирование не только вирусной ДНК, но и CpG-сайтов промоторных участков генов клеток хозяина [20].
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