Abstract
As part of a study of the catalytic mechanism of carboxypeptidase A, two proton transfers in the system Glu 270 H 2OZnHis 69-Asp 142 are treated with an ab initio MO method. Results show that the proton transfers are strongly affected by the environment. It is predicted that the proton between His 69 and Asp 142 is covalently bonded to His 69.
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