Abstract
AbstractThe binding of platinum(II) diammines to 1‐methylcytosine and guanine has been reevaluated from earlier published molecular orbital calculations, in which the Löwdin overlap charge density has been defined and evaluated for platinum–ammine bonds in the Pt(II) diammine drugs and the PN bonds involved with 1‐methylcytosine and guanine. It is also shown that the effectiveness of anticancer activity is reduced in the Pt(II) diammine drugs, with increasing methyl substitution on the ammine nitrogen. © 2001 John Wiley & Sons, Inc. Int J Quant Chem 83: 255–258, 2001
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