Abstract
5-Substituted deoxycytidines exhibit antiviral and antimetabolic properties and they are selective inhibitors of herpes simplex virus (HSV). Conformational properties of two of the 5-substituted deoxycytidines, namely: 5-ethynyl- and 5-vinyl-2′-deoxycytidines, have been investigated by the PCILO method and compared with those of their parent nucleoside (2′-deoxycytidine). The results indicate striking similarity in their conformational behaviour. This result has important biological significance in terms of their biological activity. The mechanism of their action is discussed.
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
