Molecular Oncology and Clinical Applications

Abstract

Molecular aspects of cell transformation and growth.- The Impact of Molecular Genetics on Cancer Research.- Identification of a Chimeric Gene Frequently Activated in Human Thyroid Papillary Carcinomas.- The Role of Tumor Suppressor Genes in Human Cancer Progression.- The Central Role of the IGF-1 Receptor in the Control of Cellular Proliferation.- Loss of TGF-ss Expression is a Critical Component of Malignant Progression in Multistage Carcinogenesis of the Mouse Epidermis.- Structure, Biosynthesis and Biochemical Properties of the HGF/SF Receptor.- Molecular Characterization of Trop-2, a Cell Surface Molecule Highly Expressed by Human Carcinomas - Cloning of the Gene Encoding Trop-2.- Loss of Heterozygosity and Distribution of Alleles at the VNTR Region of the HRAS Gene in Ovarian Carcinoma.- Mg2+ in the Regulation of Ascites Tumor Cell Energy Metabolism.- Effect of Quercetin on Cell Proliferation and Heat Shock Protein Synthesis Induction in K562 Erythroleukemia.- Regulation of MnSOD Expression by Manganese in Tumors.- Membrane receptors and signal transduction.- An Efficient Expression cDNA Cloning Approach to Screen Human Tumors for Oncogenes.- The Roles of Specific Isoforms of Protein Kinase C (PKC) in Signal Transduction, Growth Control and Diacylglycerol Metabolism.- Regulation of Protein Kinase C.- Potential Roles of p21ras in Growth Factor Signalling - An Overview.- p21-ras and p56-lck Mediate The Two Major T-Cell Antigen Receptor Signal Transduction Pathways.- Further Characterization of CDC25 Mm , a Mammalian Activator of p21ras.- MAP Kinase Cascade and the Control of Cell Proliferation.- Accumulation and Mitogenic Activity of Lysophosphatidylinositol in k-ras-Transformed Thyroid Cells.- Activities Involved in the Modulation of the G Protein Endogenous ADP-Ribosylation in Normal and K-ras-Transformed Thyroid Cells.- The Regulation of TNF-? Receptors in Human Osteosarcoma Cells.- Chronic Exposure to the Tumor Promoter TPA Mimics Differentiating Effects of Serum in Primary Cultures of Cerebellar Granules.- Transcriptional Control by Nuclear Receptors.- Models for new therapeutical strategies.- Therapeutic Opportunities Involving Cellular Oncogenes.- Molecular Analysis of Fine Needle Aspiration Cytologic Specimens from Suspicious Thyroid Nodules.- Tumor-associated Macrophages: Cytokine Regulation and Therapeutic Implications.- Various Cytokines (IL-2, IL-4, IFN-gamma) Show Different Efficiency in Inducing Tumor Rejection.- Adoptive Immunotherapy of Melanoma with Interleukin-2 and Lymphocytes.- GM-CSF Augments the IL-4 Induced Cytotoxic Activity of Human Peripheral Blood Mononuclear Cells in the Presence of the Mouse Monoclonal Antibody 17-1A.- Autologous Bone Marrow Transplantation with Peripheral Stem Cells In vivo Expanded by Chemotherapy and G-CSF.- The Regulatory Subunit of cAMP-Dependent Protein Kinase as a Target for Cancer Diagnosis and Therapy.- Type I Isoform of PKA is Involved in the Control of Cell Proliferation and Oncogene Transformation of Human Mammary Epithelial Cells: Therapeutic Implications.- Modulation of the Cell Response to Hyperthermia by Membrane Perturbating Agents.- MRS Studies on Experimental Tumours Treated with TNF.- Tumor Vaccines - Perspectives and Practice.- Clinical applications.- Tumor Imaging with Radiolabeled Monoclonal Antibodies and Other Specific Ligands.- Evaluation of p53 Overexpression in Bladder Cancer.- Biological Factors and Treatment Decision in Early Breast Cancer.- New Chemotherapeutic Agents: A Selection of Some of the Most Promising New Drugs.- Degradation of 5-Fluorouracil via the Pyrimidine Degradative Pathway.- Folinic Acid and 5-Fluorouracil +- Interferon Alfa-2b in the Treatment of Advanced Colorectal Cancer: Preliminary Results of a Randomized Study.- Pharmacokinetics of Free and Total Platinum Species after Prolonged Venous Infusion of Cisplatin and Concurrent Radiation Therapy for Lung Carcinoma.- The Role of Interferons in the Treatment of Solid Tumors.- Endocrine Treatment of Malignant Disease.- Interactions Between Growth Factors and Oestrogens in Breast Cancer Cells.- Potentiation of the Antitumor Activity of Tamoxifen by Interferons: A Mini-Review.- Vitamin E status is Influenced by ?-3 Polyunsaturated Fatty Acid Supplementation in Patients at Risk for Colon Cancer.- Progress Towards the Clinical Application of Somatic Cell Gene Therapy.- Intraoperative Radiation Therapy: An Overview.