Molecular modeling, total synthesis, and biological evaluations of C9-deoxy bryostatin 1.

Abstract

‘OH’ no you don't: The title compound 1 has been synthesized and evaluated for biological function. Molecular modeling of bryostatin 1 with the C1 domain of protein kinase C δ indicates that the C9OH of bryostatin 1 makes a hydrogen-bonding contact to the protein. Despite the absence of the hydrogen-bonding contact for 1, it displays bryostatin-like biological effects in four assays using either U937 leukemia cells or prostate LNCaP cells. Detailed facts of importance to specialist readers are published as ”Supporting Information”. Such documents are peer-reviewed, but not copy-edited or typeset. They are made available as submitted by the authors. Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article.