Abstract
Molecular modeling of the interaction of trypanocide aromatic guanyl hydrazones with B-DNA showed that the preferential sites for interaction are the DNA minor groove AT rich regions, with hydrogen bonding between the guanidine moiety of the drugs and the thymine O2, and the adenine N3. There is a correlation between the total interaction energy and ID 50 . Molecular modeling of the interaction of trypanocide aromatic guanyl hydrazones ( 1 ) with B-DNA showed that the preferential sites for interaction are the DNA minor groove AT rich regions.
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
