Abstract
Optimization of ionic liquid-based microwave-assisted extraction on brazilin levels from sappan wood and its dipeptidyl peptidase IV inhibition activityIslamudin Ahmad, Erwi Putri Setyaningsih, Ayun Erwina Arifianti, Fadlina Chany Saputri, Abdul Mun’im
Highlights
Type 2 diabetes mellitus (T2DM) is a chronic metabolic disease characterized by insulin resistance and insulin deficiency
Ji et al (2014) designed and synthesized novel β-amino pyrrolo-2carbonitrile derivatives and found that compound 9l showed excellent DPP4 inhibitory activity resulting in decreased blood glucose in vivo
Calculation of the values of $Z-SCORE identified S22 and S24 as outliers with $Z-SCORE values of 3.10848 and 2.7395, respectively. Both compounds should be removed from the data set to improve the quantitative structure–activity relationship (QSAR) model
Summary
Type 2 diabetes mellitus (T2DM) is a chronic metabolic disease characterized by insulin resistance and insulin deficiency. Several DPP4 inhibitors have recently been approved by Food and Drug Administration (FDA), such as sitagliptin (Merck), vildagliptin (Novartis), saxagliptin (BMS), alogliptin (Takeda), and linagliptin (Lilly) (Cox et al, 2016). Their use in the clinical application is not devoid of problems such as severe adverse effects, including hypoglycemia, edema, weight gain, and gastrointestinal distress (Li et al, 2016). The need for novel and potent antidiabetic agents with minimum side effects is indispensable. Ji et al (2014) designed and synthesized novel β-amino pyrrolo-2carbonitrile derivatives and found that compound 9l showed excellent DPP4 inhibitory activity resulting in decreased blood glucose in vivo
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