Abstract
HCV is a leading cause of liver disease and can lead to hepatocellular carcinoma and liver damage which in turn can cause death of patients. HCV is closely related to immune response especially inflammation suggesting that the immune response-related genes can serve as molecular targets for chemo-prevention and treatment of C-type HCC. This study was conducted to determine the 3D structures of immune responsive gene (CXCL6) that are up-regulated during Hepatitis C Virus (HCV) Infection and Hepatocellular Carcinoma (HCC) and HCV core protein.Furthermore, docking and interactions analysis of immune responsive gene with HCV core protein was performed to understand pathogenesis of HCV infection. Reliable 3D structures of both proteins were determined using comparative modeling approach. Docking of both proteins revealed functionally important residues i-e. Arg149, Arg39, Arg74 and Gln78 in HCV core protein and Leu44, Ala71, Ser76 and Pro97 in CXCL6. It can be concluded from the study that CXCL6 had potentially interacting residues with HCV core protein that can be helpful in finding clues to understand HCV pathogenesis and develop better therapeutic regimens.
Highlights
The Hepatitis C Virus (HCV) is the leading cause of chronic liver disease worldwide [1,2]
Literature survey was performed to find important immune responsive gene that is up-regulated during HCV infection
HCV is a major cause of hepatocellular carcinoma and because of its diverse genotypes, there is no vaccine developed to date
Summary
The Hepatitis C Virus (HCV) is the leading cause of chronic liver disease worldwide [1,2]. The immune responsive gene was selected on the basis of biological function and involvement in Hepatitis C Virus induced hepatocellular carcinoma. Viral core protein directly interacts with a number of cellular proteins and pathways involved in the viral life cycle [10] This gene was subjected to docking to find potential interactions with immune responsive gene. Analysis of this immune responsive gene with HCV core protein can help investigating their role in HCV. This information might provide clues to understanding HCV pathogenesis and develop better therapeutic regimens
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