Molecular Modeling and Drug Design: A Contemporary Analysis in Vibrio cholerae

Abstract

Vibrio cholerae causes the diarrheal disease cholera. This microbe inhabits well in human host and aquatic environments. Excessive use of antibiotics has contributed to the emergence of antibiotic resistance in V. cholerae. Quorum sensing is one of the lucrative targets presently pursued for drug design in bacteria to encounter virulence. LuxO, a response regulator, is an important part of quorum-sensing machinery in V. cholerae contributing in biofilms and virulence machinery. In this chapter, we will concisely discuss the disease, its clinical display, and distinctive methodologies to find drug targets. As a treatise on the method of drug design in V. cholerae, we used our in silico model of LuxO in this chapter, to predict probable sites of interference, and then used these sites for in silico drug design.