Molecular Medicine: Novel Findings of Gene Diagnosis, Regulation of Gene Expression, and Gene Therapy, 1999Edited by I.Hashimoto, H.Shinkawa, T.Suda, S.Tsuchida, S.Yagihashi and J.Uitto. Available from Elsevier Science BV, P.O. Box 211, 1000 AE Amsterdam, The Netherlands, or from Elsevier Science Inc., P.O. Box 945, Madison Square Station, New York, NY 10160-0757, USA. Price: US$139.50. ISBN: 0-444-50006-5.

Abstract

Book ReviewsMolecular Medicine: Novel Findings of Gene Diagnosis, Regulation of Gene Expression, and Gene Therapy, 1999 Brian MeyerPhD Brian Meyer Scientist, Department of Biological and Medical Research, MBC 03, King Faisal Specialist Hospital & Research Centre, P.O. Box 3354, Riyadh 11211, Saudi Arabia Search for more papers by this author Published Online::1 May 2000https://doi.org/10.5144/0256-4947.2000.339SectionsPDF ToolsAdd to favoritesDownload citationTrack citations ShareShare onFacebookTwitterLinked InRedditEmail AboutIntroductionThis book is based on the proceedings of the second meeting of the Hirosaki International Forum of Medical Science held in Hirosaki, Japan, in July 1998. The forum was inspired by the contribution of molecular genetics over the past decade to the explosion of knowledge of the genetic basis of many diseases. The compilation articles in the book describe advances in the diagnosis and treatment of these diseases and collectively define the field of molecular medicine. Some 27 articles cover a wide area of medicine, encompassing the molecular pathology of diseases involving skin, sensorineural, immune and other organ systems.The book is divided into three sections dealing with molecular diagnostics, gene expression and gene therapy. The articles dealing with the molecular basis and diagnosis of disease are highly focused and directed to readers with specific rather than general interests. The areas covered include cutaneous basement membrane disorders such as epidermolysis bullosa, hearing disorders, retinal degeneration, angiotensin-converting enzyme polymorphisms in lupus nephritis and the genetic basis of drug response. The section on gene expression contains impressive articles, again directed at readers with specific interests. The articles deal with receptor-ligand triggered gene expression, response to drugs, transcription factor activity and cytokine responses related to neoplasia and infection. The section on gene therapy is of more general interest. Although the articles deal with the introduction of cytokine genes into keratinocytes, readers will gain useful insight into the targeted delivery and expression of genes.My overall impression of this book is that it offers a compilation of high-standard reviews and original research in specific areas. It is an excellent reference book for a library, but is not attractive for a personal collection because the articles address very specific subjects in diverse disciplines. Previous article Next article FiguresReferencesRelatedDetails Volume 20, Issue 3-4May-July 2000 Metrics History Published online1 May 2000 InformationCopyright © 2000, Annals of Saudi MedicinePDF download