Abstract
Molecular mechanisms regulating cytotoxic lymphocyte development and function, and their associations to human diseases.
Highlights
We open the Research Topic with a review providing an up-todate view on the development and differentiation of natural killer (NK) cells, and their relationships to other innate lymphoid cells
Two complementary reviews focus on the maturation and release of lytic granules, and the high-resolution techniques that allow for visualization of lytic granules and quantification of their subsequent fusion with the plasma membrane at the contact site with target cells [5, 6]
Baginska et al [8] present a fascinating view from the opposite, target cell side, providing us with a comprehensive review of how tumor cells can affect the function of NK cells and evade cell death; these include secretion of multiple tumor-derived immunosuppressive factors and metabolites, or autophagy-mediated resistance to NK-mediated killing
Summary
We open the Research Topic with a review providing an up-todate view on the development and differentiation of NK cells, and their relationships to other innate lymphoid cells. A review by Galandrini et al [4] discusses the mechanisms underlying activation of cytolytic machinery following target cell recognition.
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