Abstract
Cell migration is an important and fundamental process. It underlies embryonic development, immune responses, and the repair and regeneration of damaged tissues. Impairments to migration are linked with many important diseases, such as tumor metastasis. The direction of migration can be regulated both by extracellular and intracellular factors. In the case of chemical extracellular factors, the directional migration of cells is called chemotaxis. This review presents a current model of the mechanisms selecting the direction of movement of mesenchymal cells, and analogies and comparisons are made with the mechanisms of chemotaxis in well studied ameboid cells.
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