Abstract
Studies of the interactions between synaptic proteins are revealing the molecular mechanisms of synaptic vesicle docking and membrane fusion. A 7S complex between the synaptic vesicle proteins synaptotagmin and VAMP, and the plasma membrane proteins syntaxin and SNAP-25 is thought to initiate the docking of vesicles. This is followed by recruitment of the soluble factors α-SNAP and the NSF ATPase to form a ∼20S particle. The hydrolysis of ATP is required for the disassembly of the complex and may ultimately result in the fusion of the membranes. Sequence similarities between syntaxin and neurexins are presented, and a possible role for neurexins in alternative complexes is suggested.
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a call
