Abstract
Recently, more information has appeared in the scientific literature on the role of synaptic pruning in the development of many diseases of the nervous system. Synaptic pruning is the elimination of excess synapses, thereby leading to optimization and increase the efficiency of the neural network. Excessive or insufficient synaptic pruning may underlie some disorders of the nervous system, including autism, schizophrenia, and epilepsy. There are also neurodegenerative diseases, which are based on the death of neurons, presumably in connection with reactivation of pruning at a later age. However, the mechanisms of synaptic pruning are not well known so far. Prior to understanding the significance of pruning in pathological conditions, it is necessary to study more in detail and consider its physiological function. This literature review reveals the main mechanisms and features of the occurrence of this process.
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a call
