Abstract
Pancreatic islet tumors are relatively rare in the general population but occur frequently in patients with MEN 1. Delineation of the genetic events leading to neoplastic transformation of islet cells is at an early stage; but based on tumor deletion studies, it appears that inactivation of the MEN 1 gene is an early step in carcinogenesis for both sporadic and MEN 1-related tumors. Limited data also suggested a role for other tumor suppressors including the retinoblastoma, adenomatous polyposis coli, and Gorlin syndrome genes. Activation of oncogenes has not been identified in pancreatic islet tumors.
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callMore From: Endocrinology and Metabolism Clinics of North America
Disclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
