Abstract
This article systematizes the results of studies on the pathogenetic mechanisms of CPPS formation in patients with EGE. Pain is one of the severe clinical manifestations and complications of endometriosis. To ease the pain in patients with EGE is complex but urgent task. Long diagnostic search (mean period 5−8 years) leads to the formation of a persistent Autonomous pain syndrome associated with relapses of pain even after a com-prehensive treatment of patients (surgical and/or long-term hormonal). Patients with endometriosis suffer from mixed pain including neuropathic and nociceptive components which is proved by the example of expression in ectopic foci of specific biomarkers. Therefore, the question of early non-invasive diagnosis of endometriosis is very vital and can be solved by the development of a diagnostic panel consisting of biomarkers expressed by ectopic foci at the initial stage of the disease.
Highlights
В статье систематизированы результаты исследований относительно патогенетических механизмов формирования синдрома хронической тазовой боли у пациенток с наружным генитальным эндометриозом
This article systematizes the results of studies on the pathogenetic mechanisms of CPPS formation in patients with EGE
Long diagnostic search leads to the formation of a persistent Autonomous pain syndrome associated with relapses of pain even after a comprehensive treatment of patients
Summary
Красноярский государственный медицинский университет имени профессора В.Ф. Войно-Ясенецкого, Красноярск, Российская Федерация. Молекулярные механизмы формирования синдрома хронической тазовой боли у пациенток с наружным генитальным эндометриозом: маркеры и мишени для диагностики и терапии (обзор литературы). Patients with endometriosis suffer from mixed pain including neuropathic and nociceptive components which is proved by the example of expression in ectopic foci of specific biomarkers. Molecular Mechanisms of Formation of Chronic Pelvic Pain Syndrome in Patients with External Genital Endometriosis: Markers and Targets for Diagnosis and Therapy (Review). Отчасти это связано с тем, что нет достоверных диагностических маркеров или их групп, которые являлись бы специфическими для этого заболевания [2−4]. Группа: СА-125, хемокиновые рецепторы, моноцитарный хемоаттрактантный протеин (Monocyte chemoattractant protein, МСР) 1
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