Abstract

Spinal cord injury (SCI) is closely related to the breakdown of blood spinal cord barrier (BSCB). The epidermal growth factor receptor (EGFR) excessive activation plays a key role in the progression of BSCB and SCI destruction. We mainly reviewed the mechanism of EGFR signaling pathway activation in pathophysiology of BSCB damage after SCI. Key words: Spinal cord injury; Epidermal growth factor receptor; Blood spinal cord barrier; Microvascular endothelial cell; Glial cell; Molecular mechanism

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