Abstract
Caveolin-1 (CAV1) is a membrane protein that promotes Rac1 activation, migration and invasion of melanoma and metastatic breast cancer cells by mechanisms that have remained elusive. Recent evidence has shown that CAV1 sequesters p85α, a GAP for the small GTPase Rab5, thereby initiating a signaling cascade that leads to Rac1 activation. Rab5 has been identified as a critical regulator not only of early endosome dynamics, but also as an important regulator of cell adhesion and migration. Moreover, a novel pathway is described, whereby CAV1 stimulates the recruitment of Tiam1 to Rab5-positive early endosomes, leading to local Rac1 activation, migration and invasion of metastatic cancer cells. Keywords: Caveolin-1, Rab5, Rac1, migration, invasion, metastasis
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