Abstract
Breast cancer (BC) has become one of the most concerned diseases among women for high incidence and poor prognosis, which also increases the attention from all over the world. Besides, a large number of researches show that the increased BMI is consistently associated with BC recent years. While the intervention strategies of obese BC patients are incomplete and unspecific now, and there is no better treatment for the complexity of BC typing, especially for triple-negative BC.
Highlights
Breast cancer (BC) is a prevalent disease that is diagnosed through imaging, clinical examination, or self-identification [1]
Trinegative breast cancer (TNBC) which lacks the expression of Estrogen receptor (ER), progesterone receptor (PR) and human epidermal growth factor receptor 2 (HER2), has a very aggressive disease course [7] and a poor prognosis, with the risk of increasing local recurrence and distant metastasis [8,9,10]
According to a meta-analysis, low serum adiponectin levels connect with the increased risk of breast cancer, and what is needed is that further investigation should be carried out to explore a threshold of adiponectin for a protective effect against BC [37]
Summary
Breast cancer (BC) is a prevalent disease that is diagnosed through imaging, clinical examination, or self-identification [1]. It is reported that obesity is inversely associated with the risk of premenopausal breast cancer [20,21,22]. The obesity of postmenopausal women makes the risk of breast cancer increasing by 30%, which accounts for 21% of all breast cancer deaths in the world [23,24,25]. Adipokines secreted mainly by adipocytes from white adipose tissue, are small peptide hormonal growth factors, and primarily lead to breast cancer with obesity.
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