Abstract
CIA is the most conserved histone chaperone in the eukaryotes. The biochemical and X-ray crystallographic studies have revealed that CIA splits the histone (H3-H4)2 tetramer into two histone H3-H4 dimers through the CIA-histone-H3-H4 complex formation. The histone (H3-H4)2 tetramer splitting activity of CIA gives new insights into the mechanism of the nucleosome assembly/disassembly, the relationship between nucleosome assembly/disassembly and epigenetic modifications of histones, and the mechanism of the epigenetic information inheritance through the semi-conservative nucleosome replication mode.
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