Abstract
Introduction: Obesity represents a fast growing health problem that is reaching epidemic proportions worldwide and is associated with an increased risk of premature death. Obesity significantly increases the risk of developing type 2 diabetes mellitus, hypertension, coronary heart disease, stroke, and several types of cancer. Vaspin (visceral adipose tissue-derived serpin) was identified as an adipokine with insulin-sensitizing effects, which is predominantly secreted from visceral adipose tissue in a rat model of type 2 diabetes (T2D). We recently reported that elevated vaspin serum concentrations are associated with obesity and impaired insulin sensitivity in humans. It has therefore been postulated that increased vaspin expression and secretion could represent a compensatory mechanism associated with obesity, severe insulin resistance, and type 2 diabetes. Although, antiprotease properties have been suggested as mechanism of vaspin action, until now a protease substrate of vaspin has not been identified.
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