Molecular mechanism of pyroptosis in sepsis

Abstract

Sepsis is a disease with a high mortality rate worldwide, which seriously threatens human life and health. Due to the complexity of its pathogenesis, diagnosis and treatment are often very difficult. Pyroptosis is a newly discovered pro-inflammatory form of programmed cell death, which occurs predominantly in professional phagocytes.During sepsis, appropriate pyroptosis is required for defense against bacterial infection, however, excessive pyroptosis will also aggravate the inflammatory reaction of sepsis. Therefore, the study of the signaling pathways and regulatory mechanisms of pyroptosis in sepsis may contribute to identify potential therapeutic targets. Hence, the study provide an overview of the recent advances which focus on the two signaling pathway of pyroptosis, some caspases which have found new effects, GSDM family and the crosstalk between different form of cell death. Key words: Sepsis; Bacterial infection; Reaserch; Pyroptosis; Imflammasome