Abstract
Eighty percent of human infections are caused from persistent biofilm communities that have become resistant to antibiotics. Pathogenesis as simple as dental plaque buildup to medical device transplant complications are in need of novel antimicrobial endeavors to combat persistent bacterial infections. The objective of this study is to elucidate the activation mechanism of a bacterial Histidine Kinase from Bacillus subtilis, KinC, which initiates a signal transduction cascade leading to biofilm formation.
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