Abstract
Molecular mechanism of peritoneal dissemination in gastric cancer
Highlights
Gastric cancer (GC) is one of the most prevalent cancers worldwide and is associated with a high mortality rate[1]
We recently found that ADP-ribosylation factor-like 4C (ARL4C) is associated with peritoneal dissemination (PD) in GC, possibly by promoting the invasive capacity of cancer cells via activation of both epithelial-mesenchymal transition (EMT) and actin cytoskeleton reorganization[22]
We focused on the influence of EMT on PD and found that discoidin domaincontaining receptor 2 promoted PD in GC via induction of EMT[34]
Summary
Gastric cancer (GC) is one of the most prevalent cancers worldwide and is associated with a high mortality rate[1]. Detachment from the primary tumor Adaptation to the peritoneal cavity microenvironment Attachment toperitoneal mesothelial cells and tumor growth The lymphatic metastasis and hematogenous metastasis are the major dissemination processes in solid cancers, PD is the most frequent metastatic type in GC patients, according to the annual report 2009 from Japanese Gastric Cancer Association. The first step involves detachment of cancer cells from the primary tumor, followed by survival of the cells in the microenvironment of the peritoneal cavity.
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