Molecular mechanism of mechanical interaction between temporal expression of progerin and nuclear deformation

Abstract

The cell nucleus is wrapped by nuclear lamina consisting of A type (LMNA) and B type (LMB1/2) lamin proteins under nuclear envelope (NE). The nuclear lamina interacts with the intranuclear organization and cytoskeletal structure via the linker of the nucleoskeleton and cytoskeleton (LINC) complexes, which provides the nucleus with structural framework that directly implicates the mechanical integrity of the whole nucleus system. Recent studies have shown mutations in the LMNA encoding the lamin A and C cause numerous genetic disorders.