Abstract
The incidence of prostate cancer has been greatly increased in China and it has ranked the 5th of the malignant tumors in Chinese males.Continuous environment stimulation causes chronic prostatic inflammation,and infiltration of inflammatory cytokines such as INF-γ,TNF-α,and TGF-βcan cause damage and repair of prostatic tissues,leading to proliferative inflammatory atrophy(PIA).Then a small subset of cells will develop somatic genome alterations,including overexpression of MYCand the loss of NKX3.1and PTEN,which can promote PIA into prostatic intraepithelial neoplasia.Androgen receptor mutation and ERG-TMPRSS2 fusion will drive progression of prostatic cancer.
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