Abstract
Two proteins called Sec17 and Sec18 may have a larger role in membrane fusion than is commonly assumed in textbook models.
Highlights
Related research article Song H, Torng TL, Orr AS, Brunger AT, Wickner WT. 2021
A protein called NSF was one of the first to be associated with membrane fusion, and it was postulated that NSF was part of a ’fusion machine’ made of multiple subunits (Malhotra et al, 1988)
It was later found that NSF binds to sites in the membrane with the help of proteins named SNAPs, which are the mammalian homologues of the yeast protein Sec17 (Whiteheart et al, 1992)
Summary
Related research article Song H, Torng TL, Orr AS, Brunger AT, Wickner WT. 2021. Sec17/Sec18 can support membrane fusion without help from completion of SNARE zippering. eLife 9:e67578. doi: 10.7554/ eLife.67578. M any biological processes require two membranes to fuse together, such as the release of neurotransmitters from synaptic vesicles in neurons and the fusion of vacuoles in yeast. Further research led to the discovery that three proteins that had previously been implicated in neurotransmitter release were SNAP receptors (SNAREs) and formed a large membrane-anchored assembly with NSF and SNAP called the 20S complex (Sollner et al, 1993b).
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
