Abstract
Two hydrophobic parameters (log k w−C18 and log k w−IAM, respectively) of a huperzine A series were extrapolated by high performance liquid chromatography (HPLC) using both C18 and immobilised artificial membrane (IAM) columns. A mathematical correlation between C18 and IAM hydrophobic parameters was completed, suggesting a similar behaviour on both columns. This behaviour was principally led by hydrophobic forces. The theoretical lipophilicity (log P) of each compound was computed using Pallas ® software and compared to experimental values, showing a similar lipophilic behaviour. Finally, the huperzine log k w−IAM and log k w−C18 values were correlated with the relative bound percentage of huperzine in human serum albumin, confirming that hydrophobic forces are predominant in the huperzine–HSA binding mechanism.
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