Molecular Interactions of Sodium Dodecyl Sulphate with a Sulpha Drug and its Nanoaggregates in Aqueous System

Abstract

AbstractInteraction study between sulfanilamide (SM) and sodium dodecyl sulfate (SDS) in an aqueous environment has been conducted using electrical conductivity, emission, and absorption spectroscopy techniques. Conductivity measurements were performed over the temperature range of (288.15 to 318.15) K and SM concentrations ranging from (c=0.005 to 0.03) mol ⋅ L−1. Thermodynamic parameters: Gibbs free energy (ΔGom), enthalpy (ΔHom), and entropy (ΔSom) associated with micellization have been calculated. To further investigate the interactions between (SM and SDS), the absorption and emission spectroscopy were employed at premicellar concentrations of SDS. Resulting SM‐SDS conjugate was then utilized to examine its interaction behavior with electrolytes and vitamins commonly found in biofluids namely chlorides and sulfates of sodium, potassium, magnesium, and calcium, along with L‐ascorbic acid (LAA) and nicotinic acid (NA). Moreover, SM drug has been transformed into its nanoaggregates (SMNA). These nanoaggregates have been characterized using dynamic light scattering (DLS), scanning electron microscopy (SEM), and transmission electron microscopy (TEM). Interactions between SMNA‐SDS conjugates were also studied in the presence of the above‐mentioned electrolytes and vitamins. The findings of this study have been interpreted within the context of the interactions occurring in the solution phase. This research provides valuable insights into the complicated interactions between SM, SDS, electrolytes, and vitamins in aqueous system.