Abstract
Physicochemical characterization is a crucial step for the successful development of solid dispersions, including the determination of drug crystallinity and molecular interactions. Typically, the detection of molecular interactions will assist in the explanation of different drug performances (e.g., dissolution, solubility, stability) in solid dispersions. Various prominent reviews on solid dispersions have been reported recently. However, there is still no overview of recent techniques for evaluating the molecular interactions that occur within solid dispersions of poorly water-soluble drugs. In this review, we aim to overview common methods that have been used for solid dispersions to identify different bond formations and forces via the determination of interaction energy. In addition, a brief background on the important role of molecular interactions will also be described. The summary and discussion of methods used in the determination of molecular interactions will contribute to further developments in solid dispersions, especially for quick and potent drug delivery applications.
Highlights
Soluble or insoluble drugs result in low absorption, which certainly affects drug bioavailability, especially in oral drug delivery [1,2,3,4,5]
Many pieces of information can be obtained, such as how the polymer affects drug crystallinity, how the molecular interactions between the drug and the components in the formulation occur and how the binding force is generated. The data from these studies will be useful in the explanation of different drug performances and will contribute to the selection of the best formulation in drug development
In 1998, Taylor et al used Raman spectroscopy to quantitate the degree of indomethacin crystallinity in mixtures of its crystal and amorphous states [82]
Summary
Soluble or insoluble drugs result in low absorption, which certainly affects drug bioavailability, especially in oral drug delivery [1,2,3,4,5]. Many pieces of information can be obtained, such as how the polymer affects drug crystallinity, how the molecular interactions between the drug and the components in the formulation occur and how the binding force is generated. The data from these studies will be useful in the explanation of different drug performances and will contribute to the selection of the best formulation in drug development. The molecular interaction (for example, between griseofulvin and hydroxypropyl bonds formation kinetics methylcellulose acetate succinate) is even maintained in the liquid state, as demonstrated in the study of Al-Obaidi et al [44]. Poorlymay water-soluble drug will be described below, depends on the physicochemical properties of SDs rather than their
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