Molecular Interactions between Saliva and Dental Composites Resins: A Way Forward.

Veaceslav Șaramet,Mihaela Pantea,Marina Meleșcanu-Imre,Crenguța Cristina Albu,Alexandra Ripszky-Totan,Ana Maria Cristina Țâncu

doi:10.3390/ma14102537

Veaceslav Șaramet, Mihaela Pantea + Show 4 more

Open Access

https://doi.org/10.3390/ma14102537

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Journal: Materials	Publication Date: May 13, 2021
Citations: 9	License type: CC BY 4.0

Affiliation: Carol Davila University of Medicine and Pharmacy

Abstract

Dentin and enamel loss related to trauma or especially caries is one of the most common pathological issues in dentistry that requires restoration of the teeth by using materials with appropriate properties. The composite resins represent dental materials with significant importance in today’s dentistry, presenting important qualities, including their mechanical behavior and excellent aesthetics. This paper focuses on the saliva interactions with these materials and on their biocompatibility, which is continuously improved in the new generations of resin-based composites. Starting from the elements involved on the molecular landscape of the dental caries process, the paper presents certain strategies for obtaining more advanced new dental composite resins, as follows: suppression of oral biofilm acids formation, promotion of remineralization process, counteraction of the proteolytic attack, and avoidance of cytotoxic effects; the relation between dental composite resins and salivary oxidative stress biomarkers is also presented in this context.

Highlights

Dental composite resins represent some of the most used materials in modern dentistry
The aim of this paper is to synthesize the complex interactions of dental composite resins with the oral environment, especially with saliva: suppression of biofilm acids formation, remineralization process, counteraction of the proteolytic attack, avoidance of cytotoxic effects, oxidative stress related issues
Wang et al studies on S. mutans have revealed that DMADDM containing adhesives were able to trigger bacterial cells’ growth limitation, acid production, and exopolysaccharides synthesis inhibition, without affecting the dentin bond strength [43]

Summary

Introduction

Dental composite resins represent some of the most used materials in modern dentistry. Composite resins represent dental materials providing a very good biocompatibility within the oral environment [1,2]. The aim of this paper is to synthesize the complex interactions of dental composite resins with the oral environment, especially with saliva: suppression of biofilm acids formation, remineralization process, counteraction of the proteolytic attack, avoidance of cytotoxic effects, oxidative stress related issues. This approach reflects the valuable properties of dental composite resins, as well as certain aspects regarding adverse effects potentially caused by them. The elements addressed in this paper have, a practical connotation, as dentists should be permanently informed and aware about the biomechanical properties of dental materials—especially of the new ones—and should personalize the selection of restoration materials, in accordance with the complexity of each clinical case

New Elements from the Chemical Landscape of Novel Composite Resins

Suppression of Biofilm Acids Production

Promoting of the Remineralization Process

The Counteracting of the Proteolytic Attack

Avoiding the Cytotoxic Effects

Conclusions