Molecular Interaction Activities of Phenylephrine Hydrochloride with Aqueous System by using Physicochemical Properties at 298.15, 303.15, 308.15 and 313.15 K

Abstract

Abstract: The solubilizing tendency of the phenylephrine hydrochloride (PHC) with water was supported by the intermolecular interaction (IMI). The effect of PHC concentration with water molecules on the interaction by using physicochemical properties (PCP) was investigated at 298.15, 303.15, 308.15 and 313.15 K. The PCP such as density (ρ, g cm -3 ), Apparent Molar Volume (Vϕ,cm 3 ·mol−1 ), viscosity (η, mPa.s), and surface tension (γ,mNm-1 ) of PHC in aqueous solution have been determined at 298.15, 303.15, 308.15 and 313.15 K. The PCP determine the state of intermolecular forces (IMF) between PHC and water (W). The concentration of PHC ranged from 0.02- 0.10 millimolar (mM) as a binary system in water. This study shows molecular interaction mechanism moderated through PCPs to assess state of IMF produced on PHC-Water interaction at 298.15, 303.15, 308.15 and 313.15 K which revealed that structural potential of PHC with water responsible for develop interaction. The PCP data confirms structural behavior of PHC with water for intermolecular interaction and increases with increasing concentration of PHC. The temperature dependent solubility determined at 298.15, 303.15, 308.15 and 313.15 K which indicates that on increasing temperature the significant change found in PCP. This is due to structure breaking effects of PHC with water furnished disruption of hydrogen bond (HB) in water and electrostatic interactions (EI).