Molecular insights into error-prone DNA replication and error-free lesion bypass.

Abstract

6·4 pp CPD error propensity when dealing with undamaged DNA, which distinguishes them from known high-fidelity DNA polymerases. Most of their biological roles and functions have not been elucidated yet. Nevertheless, recent investigations suggest the involvement of pol L together with poll;, in error-prone translesion DNA synthesisPJ Furthermore, it has been shown that pol L possesses lyase activity, which suggests that the enzyme may be involved in DNA repair processes.14J DNA polymerase l] is unique among the eukaryotic polymerases since it has the ability to perform error-free bypass synthesis through (PD lesions, which are poorly removed