Abstract
Tuberculosis (TB) is an infectious disease caused by Mycobacterium tuberculosis (Mtb) and poses a severe threat to human health. Therefore, finding new anti-TB drugs and targets is of great importance. One of the targets is Mycobacterial membrane protein Large 3 (MmpL3), a member of the resistance-nodulation-division (RND) class of transporters located in the inner membrane (IM). The MmpL3 protein is critical for transporting trehalose monomycolates (TMMs), the most abundant outer membrane lipids of Mtb, from the IM to the periplasmic space.
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