Abstract
Molecular imprinting is the technology of creating artificial recognition sites in polymeric matrices which are complementary to the template in their size, shape and spatial arrangement of the functional groups. Molecularly imprinted polymers (MIPs) and their incorporation with various transducer platforms are among the most promising approaches for detection of several analytes. There are a variety of molecular imprinting techniques used for the preparation of biomimetic sensors including bulk imprinting, surface imprinting (soft lithography, template immobilization, grafting, emulsion polymerization) and epitope imprinting. This chapter presents an overview of all of these techniques with examples from particular publications.
Highlights
Molecular imprinting is the technology of creating artificial recognition sites in polymeric matrices which are complementary to the template in their size, shape and spatial arrangement of the functional groups
There are different types of surface imprinting like soft lithography, template immobilization including microcontact imprinting, grafting and emulsion polymerization which have been used successfully in previous reports
The results revealed that, even if both caffeine and theophylline were present in the same sample, rebinding of theophylline to the Molecularly imprinted polymers (MIPs) was preferential and demonstrated selectivity towards theophylline
Summary
Molecular imprinting is the technology of creating artificial recognition sites in polymeric matrices which are complementary to the template in their size, shape and spatial arrangement of the functional groups. Molecular imprinting technology has been used for the creation of biorecognition surfaces on biosensors. There are different types of molecular imprinting techniques, including bulk imprinting, surface imprinting and epitope imprinting. There are different types of surface imprinting like soft lithography, template immobilization including microcontact imprinting, grafting and emulsion polymerization which have been used successfully in previous reports. All of these techniques have some advantages and at the same time limitations when it comes into applications, in general; molecular imprinting technology is very promising to create highly specific, sensitive and long-term stable biorecognition cavities on biosensor surfaces to be used in many applications
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