Abstract
Background and Aim: Cryptosporidium parvum and Hymenolepis nana are intestinal parasites that are commonly found in the unclean environment. Their presence in rats promotes the transmission of the cryptosporidiosis and hymenolepiasis to humans or animals nearby. This study aimed to determine the molecular characteristics of C. parvum and H. nana and their distribution in rats on Lombok Island. Materials and Methods: C. parvum and H. nana were investigated in 50 rats from Lombok Island. The molecular-parasitological technique used was polymerase chain reaction and sequencing method. Results: From 50 samples of rats' stool from 10 locations on Lombok Island, 8% (4/50) of C. parvum was detected molecularly with an 18S rRNA gene and 2% (1/50) of H. nana with COX 1 gene. Phylogenetic analysis indicated that C. parvum carrying rats on Lombok Island have a genetic relationship with C. parvum with Obi7 isolates, Japan and H. nana has a genetic relationship with Rodentolepis nana identified with Hn-VT isolates, India. Conclusion: The highest incidence of parasites was found in rats that were caught in the urban areas of Lombok Island, West Nusa Tenggara, Indonesia. Immediately, public health programs in these types of contaminated areas should receive priority attention to prevent further transmission of the parasites from animals to human beings.
Highlights
Diarrhea is a common global disease in both developed and developing countries
Phylogenetic analysis indicated that C. parvum carrying rats on Lombok Island have a genetic relationship with C. parvum with Obi7 isolates, Japan and H. nana has a genetic relationship with Rodentolepis nana identified with Hn-VT isolates, India
The highest incidence of parasites was found in rats that were caught in the urban areas of Lombok Island, West Nusa Tenggara, Indonesia
Summary
The cause of diarrhea generally occurs due to bacterial, fungal, viral, or parasitic infection. Diarrhea if not resolved properly, can cause death and become a significant burden on a country’s economic development as well as medical resources. Parasites are one group of pathogens that contribute to diarrhea in developing countries and countries with low economic level. The transmission can occur by any kind of animal, and rats are one common carrier [1,2]. Cryptosporidium parvum and Hymenolepis nana are intestinal parasites that are commonly found in the unclean environment. Their presence in rats promotes the transmission of the cryptosporidiosis and hymenolepiasis to humans or animals nearby. This study aimed to determine the molecular characteristics of C. parvum and H. nana and their distribution in rats on Lombok Island
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