Abstract
The aim of this study was to assess prevalence and genetic variability of hepatitis A virus (HAV) isolates in monkeys born and kept at Adler Primate Center, as well as in imported animals. The fecal samples from various species of monkeys (n=119) were studied using reverse transcription seminested PCR, sequencing, and phylogenetic analysis. HAV RNA was detected in 2 Macaca mulatta and 1 Macaca fascicularis (3.8%) kept at Adler Primate Center (n=79) and in 11 (27.5%) Chlorocebus pygerythrus (n=40) imported from Tanzania. Phylogenetic analysis demonstrated that all HAV strains belonged to simian genotype V, but differed from the prototype genotype V strain (AGM-27) by 5.4%-5.5%. Sequences isolated in this study differed by only 0.1%, suggesting a common source of infection. This study demonstrated the asymptomatic circulation of HAV genotype V among the monkeys at Adler Primate Center, and it indicated the significant genetic diversity within this HAV genotype.
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