Year-end Sale % OFF 
Abstract
Cutaneous T-cell lymphomas are a heterogeneous group of T-cell lymphoproliferative diseases affecting the skin. Mycosis fungoides and Sezary syndrome are the most studied variants of them. The literature review includes the latest published data on the pathological processes development in mycosis fungoides and Sezary syndrome and the diagnosis of these diseases. The genomic instability features in cutaneous T-cell lymphomas are described, the existing hypotheses of the origin of these diseases are considered based on the results of T-cell receptor repertoire studying.
Highlights
Molecular genetic features of cutaneous T-cell lymphomas development on example of mycosis fungoides and Sezary syndrome
Cutaneous T-cell lymphomas are a heterogeneous group of T-cell lymphoproliferative diseases affecting the skin
The genomic instability features in cutaneous T-cell lymphomas are described, the existing hypotheses of the origin of these diseases are considered based on the results of T-cell receptor repertoire studying
Summary
Molecular genetic features of cutaneous T-cell lymphomas development on example of mycosis fungoides and Sezary syndrome. Как классический метод определения клональности, так и NGS не требуют осо бого приготовления биологического материала; для работы могут быть использованы фиксированные в формалине, залитые парафином ткани кожи после рутинного гистологического и иммуногистохимичес кого исследования. При ГМ / СС отмечаются точечные мутации (в 5,4 % случаев) и увеличение числа копий (23 %) в гене CARD11, что приводит к увеличению активации NF-κB [29].
Sign-in/Register to view highlights & summary Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
