Abstract
AIM: to analyze the literature on the molecular genetic characteristics in patients with peritoneal carcinomatosis and liver metastases of colorectal cancer. PATIENTS AND METHODS : RSCI, Google Scoolar, PubMed, Web of Science databases were used for review. Over 200 literature sources on the given subject were analyzed, of which 67 were included in this review. RESULTS: in the review, the data on molecular genetic changes occurring during peritoneal carcinomatosis and liver metastases in patients with colorectal cancer were presented. The key points for treatment patients with metastatic colorectal cancer were identified. CONCLUSION: the presented data summarizes molecular genetic studies, which in turn enable clinical oncologists, surgeons and chemotherapists to determine treatment modality.
Highlights
ЦЕЛЬ: провести анализ литературы, посвящённой молекулярно-генетическим особенностям у больных перитонеальным карциноматозом и метастазами рака толстой кишки в печень
PATIENTS AND METHODS: RSCI, Google Scoolar, PubMed, Web of Science databases were used for review
RESULTS: in the review, the data on molecular genetic changes occurring during peritoneal carcinomatosis and liver metastases in patients with colorectal cancer were presented
Summary
Wnt/β-catenin локализована на границе раздела опухоль-хозяин и в сформировавшихся опухолях. Ассоциирована с ранним событием превращения аденомы в карциному; используется также в качестве маркера клеточной адгезии
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