Abstract
<p>Medicinal plants confer protective effects against a wide range of cancers including colon cancer. <em>Cichorium endivia</em> L. has many biological activities and functions, such as anti-inflammation and hepatoprotective effects. This activity is mainly due to its high levels of antioxidant compounds. The effect of cichorium extract and fluorouracil (5-FU) against colorectal cancer (CRC) induced by 1, 2- Dimethyl hydrazine (DMH) was examined in male albino mice. Where, different doses of cichorium extract (200, 400 and 600 mg/kg body weight) were investigated to determine the significant effective dose against colorectal cancer using differential display-PCR (DD-PCR), DNA sequencing, histopathological and cytological techniques. The results showed that the cichorium extract dose 200 mg/kg body weight was the best one compared to the others (400 and 600 mg/kg body weight). This finding could be a powerful therapeutic against colorectal cancer.</p><p> </p>
Highlights
Colorectal cancer (CRC) is a malignant tumor arising from the inner wall of the large intestine
The aim of the current study is to investigate the therapeutic effect of Cichorium endivia L. against Dimethyl hydrazine (DMH)-induced colorectal cancer in male albino mice using differential display-PCR (DD-PCR) and DNA sequencing
The results indicate that there are more than 247 band patterns obtained for scanning the cDNA in colon cancer mice tissues
Summary
Colorectal cancer (CRC) is a malignant tumor arising from the inner wall of the large intestine (the colon). Colorectal cancer (CRC) is the third most common cancer in both men and women and it is the second leading cause of cancer-related mortality in the developing countries due to the limited prevention and treatment options [1]. Fluorouracil (5-FU) is a drug that is a pyrimidine analog which is used in the treatment of cancer. It is a suicide inhibitor and works through irreversible inhibition of thymidylate synthase. It belongs to the family of drugs called the antimetabolites. The natural components of this vegetable have many biological activities
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