Abstract
Pancreatic cancer is a highly aggressive disease with a high mortality rate in need of innovative diagnostic and therapeutic approaches. In recent years, due to the development of molecular genetic methods a large amount of data has appeared on the genetic and epigenetic alterations that occur in pancreatic cancer, and the genetic landscape of this disease has been determined. Additionally, the genetic factors underlying the multistep carcinogenesis in precursor lesions of the pancreas have been clarified. This review highlights the pathways of carcinogenesis in the pancreas, as well as the molecular genetic processes underlying it.
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