Molecular evolution of the urotensin II gene family

Abstract

Event Abstract Back to Event Molecular evolution of the urotensin II gene family Hervé Tostivint1, 2*, Emilie Hameury2, Caroline Parmentier3, Christophe Dubessy2, Hubert Vaudry2, André Calas3, 4 and Isabelle Lihrmann2 1 CNRS UMR 5166, Evolution des Régulations Endocriniennes, France 2 Université de Rouen, Différenciation et Communication Neuronale et Neuroendocrine, France 3 Universite Pierre et Marie Curie, Neurobiologie des Signaux Intercellulaires, France 4 University Bordeaux 2, Physiopathologie de la Plasticité Neuronale, France Urotensin II (UII) is a cyclic peptide, which has been initially characterized from the urophysis of teleost fish based on its vasoactive properties. Subsequent studies have demonstrated the existence of UII in all vertebrate classes, from lampreys to mammals, including human. The occurrence of a UII molecular variant named UII-related peptide (URP) has been reported in tetrapods and, more recently, in teleosts. The UII and URP genes are located in two paralogous chromosomal regions indicating that they arose by a segmental duplication event, which probably occurred before the gnathostome radiation. Moreover, it has been proposed that the UII gene arose even earlier, by a local duplication of the somatostatin gene. In mouse, as in chicken, the UII and URP gene expression patterns have been shown to strongly overlap within motoneurons of the brainstem and the spinal cord. In contrast, in zebrafish, they appear to be very different. Indeed, while the UII gene is expressed almost exclusively in Dahlgren cells of the caudal neurosecretory system, the URP gene appears to be expressed in the spinal cord as well, but in small cells that occur much more rostrally than Dahlgren cells, in close contact with the ventral side of the central canal. These cells may correspond to cerebrospinal fluid-contacting neurons. Taken together, these results suggest that UII and URP exert very different functions in tetrapods and fish. Conference: 3rd Mediterranean Conference of Neuroscience , Alexandria, Egypt, 13 Dec - 16 Dec, 2009. Presentation Type: Oral Presentation Topic: Symposium 12 – Comparative Neuroendocrinology: novel neurochemical systems Citation: Tostivint H, Hameury E, Parmentier C, Dubessy C, Vaudry H, Calas A and Lihrmann I (2009). Molecular evolution of the urotensin II gene family. Front. Neurosci. Conference Abstract: 3rd Mediterranean Conference of Neuroscience . doi: 10.3389/conf.neuro.01.2009.16.045 Copyright: The abstracts in this collection have not been subject to any Frontiers peer review or checks, and are not endorsed by Frontiers. They are made available through the Frontiers publishing platform as a service to conference organizers and presenters. The copyright in the individual abstracts is owned by the author of each abstract or his/her employer unless otherwise stated. Each abstract, as well as the collection of abstracts, are published under a Creative Commons CC-BY 4.0 (attribution) licence (https://creativecommons.org/licenses/by/4.0/) and may thus be reproduced, translated, adapted and be the subject of derivative works provided the authors and Frontiers are attributed. For Frontiers’ terms and conditions please see https://www.frontiersin.org/legal/terms-and-conditions. Received: 19 Nov 2009; Published Online: 19 Nov 2009. * Correspondence: Hervé Tostivint, CNRS UMR 5166, Evolution des Régulations Endocriniennes, Paris, France, htostivi@mnhn.fr Login Required This action requires you to be registered with Frontiers and logged in. To register or login click here. Abstract Info Abstract The Authors in Frontiers Hervé Tostivint Emilie Hameury Caroline Parmentier Christophe Dubessy Hubert Vaudry André Calas Isabelle Lihrmann Google Hervé Tostivint Emilie Hameury Caroline Parmentier Christophe Dubessy Hubert Vaudry André Calas Isabelle Lihrmann Google Scholar Hervé Tostivint Emilie Hameury Caroline Parmentier Christophe Dubessy Hubert Vaudry André Calas Isabelle Lihrmann PubMed Hervé Tostivint Emilie Hameury Caroline Parmentier Christophe Dubessy Hubert Vaudry André Calas Isabelle Lihrmann Related Article in Frontiers Google Scholar PubMed Abstract Close Back to top Javascript is disabled. Please enable Javascript in your browser settings in order to see all the content on this page.