Abstract
To assess molecular evolution of the respiratory syncytial virus (RSV) fusion gene, we analyzed RSV-positive specimens from 123 children in Canada who did or did not receive RSV immunoprophylaxis (palivizumab) during 2006–2010. Resistance-conferring mutations within the palivizumab binding site occurred in 8.7% of palivizumab recipients and none of the nonrecipients.
Highlights
Human respiratory syncytial virus (RSV) is the most common cause of acute respiratory tract infections (RTIs) and a major cause of hospital admission and death among children
F-gene analysis was performed on 11 RSV-positive clinical samples from palivizumab recipients retrospectively identified by using neonatal clinic registries at McMaster Children’s Hospital (Hamilton, Ontario, Canada) and Montréal Children’s Hospital (Montréal, Québec, Canada) during 2009–2010
Along with the newly generated nucleotide sequences from the 123 children (23 palivizumab recipients; 100 nonrecipients), we analyzed 92 clinical respiratory syncitial virus fusion (RSV-F) sequences provided by other investigators [10,11] or available from GenBank
Summary
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